Diabetes susceptibility
نویسندگان
چکیده
منابع مشابه
Genetic Susceptibility to Transient and Permanent Neonatal Diabetes Mellitus
Neonatal diabetes mellitus (NDM) is a rare kind of diabetes characterized by hyperglycemia and low levels of insulin. Clinically, it is categorized into two main types: transient NDM (TNDM) and permanent NDM (PNDM). These types are diagnosed based on duration of insulin dependence early in the disease. In TNDM, diabetes begins in the first few weeks of life with remission in a few months. Howev...
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The authors previously showed that an A/G splicing site single nucleotide polymorphism in the OAS1 gene is strongly correlated to the basal activity of the antiviral oligoadenylate synthetase (OAS). Basal activity was highest in individuals with the GG genotype and lowest in those with the AA genotype. In the present study, OAS1 GG and GA genotypes were increased in type 1 diabetic individuals ...
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Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the Nrdp1 target Parkin, a master regulator of mitophagy. Islets from mice with pan...
متن کاملThe genetics of diabetes susceptibility in mice.
The factors associated with a diabetes-susceptible genotype in mice exhibiting various forms of heritable glucose intolerance syndromes are discussed. Genetic models of insulin-dependent and non-insulin-dependent diabetes in mice are described. Although single gene mutations can be defined for each model that are major contributors to diabetogenic stress, polygenic interactions are required for...
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Considering that MAPK (mitogen- activated protein kinase) signaling pathway has an important role in the progression of inflammatory cytokine secretion in type 2 diabetes mellitus (T2DM), we have recently investigated the reported genetic polymorphism from genome wide association study in MAP3K1 (mitogen-activated protein kinase kinase kinase 1) in diabetes as an important member of MAPK signal...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2006
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.1060018